Cancer Therapy: Fresh Insight for a New Approach ATP Depletion + Pyrimidine Depletion Can Markedly Enhance
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ATP Depletion 1 Pyrimidine Depletion Can Markedly Enhance Cancer Therapy: Fresh Insight for a New Approach
In the 1980s, necrosis was considered the mode of cell death induced by DNA-damaging anticancer agents because of the activity of PARP. PARP is activated by the DNA strand breaks caused by anticancer agents and cleaves the glycolytic coenzyme, NAD, leading to formation of poly(ADP-ribose) moieties. The ensuing depletion of NAD inhibits glycolytic generation of ATP with consequent ATP depletion,...
متن کاملATP depletion + pyrimidine depletion can markedly enhance cancer therapy: fresh insight for a new approach.
In the 1980s, necrosis was considered the mode of cell death induced by DNA-damaging anticancer agents because of the activity of PARP. PARP is activated by the DNA strand breaks caused by anticancer agents and cleaves the glycolytic coenzyme, NAD, leading to formation of poly(ADP-ribose) moieties. The ensuing depletion of NAD inhibits glycolytic generation of ATP with consequent ATP depletion,...
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